Mastiff Mixes: 43 Powerful and Unique Crossbreeds

Mastiff mixed breeds

Mastiff mixes are powerful, loving, and courageous family companions. These formidable hybrids are true giants in the canine world with their immense size and great personality, thanks to having a Mastiff parent.

As the Mastiff dog breed wonderfully combines strength and gentleness, crossing it with other purebreds brings about truly interesting and worthwhile companions and family protectors.

That said, if you are interested in meeting the incredible Mastiff mixes, keep reading! This article lists the popular and seemingly unlikely Mastiff hybrids with all their unique and lovable traits.

43 Mastiff Mixes

The Mastiff, also known as the Old English Mastiff, is an ancient dog breed that initially served as a hunter and war dog. 

Although it is a fearless protector, it is likewise a well-loved family pet due to its gentleness and loyalty toward its loved ones.

When paired with another breed by reputable breeders who wish to improve the Mastiff’s characteristics, a one-of-a-kind mix is produced. This bears the blended physical traits and personality attributes of the Mastiff and the other parent breed.

With that, let’s take a look at the 43 remarkable and unique Mastiff mixes:

1. American Masti-Bull

American Masti Bull American Bulldog Mastiff mix
Image credit: cutiepiethebear / Instagram

Parent Breeds: American Bulldog & Mastiff

As a confident protector and gentle, loyal family pet, the American Bulldog Mastiff mix, or American Masti-Bull, bears an intimidating yet cuddly dog appeal.

You’ll mostly see American Bulldog Mastiff mixes sporting a brindle coat pattern. But, they can also come in other coat colors similar to the Mastiff and American Bulldog. 

This mixed breed, weighing between 60 and 230 pounds, can seem menacing with its strong and well-muscled physique. 

But at the same time, the kind temperament, patience, and devotion the Mastiff American Bulldog mix has for its loved ones make it a genuinely endearing family member.

In addition, the Mastiff American Bulldog mix is not one to bark unnecessarily as it inherits the quiet tendencies of the Mastiff and American Bulldog. 

As such, whenever this mix barks, it is only usually trying to alert its owners of any perceived threat or intruders.

2. Boxmas

Boxmas Boxer Mastiff mix
Image credit: otis.themastiffmix / Instagram

Parent Breeds: Boxer & Mastiff

The patient and protective Boxer Mastiff mix is an outstanding family guardian with a lively personality. These energetic hybrids simply adore their human pack and are especially great with children.

A distinct black mask is part of the trademark look of the Boxmas. It is likewise common to see these canines with fawn and brindle coat colors.

In addition, this large mixed breed can stand anywhere from 23 to 36 inches in height. 

Like the Mastiff dog, the Boxer Mastiff mix is vigilant and fearless in defending its loved ones. At the same time, its playful nature makes it always eager for fun activities with its family.

And because it can get very attached and protective of its family, it is important that this mix be properly socialized early on to help it get accustomed to being around strangers.

3. Daniff

Daniff Great Dane Mastiff mix
Image credit: thegatekeeper094 / Instagram

Parent Breeds: Great Dane & Mastiff

The Daniff, otherwise called the Great Dane Mastiff mix, is an alert family guardian that is also calm, affectionate, and patient. 

This unique pairing of the purebred Great Dane and the Mastiff breed produces a laid-back family member that enjoys downtime spent with loved ones. 

While it appreciates a laid-back lifestyle, this mix also gladly welcomes playtime and fun adventures with its humans.

And though it is an easygoing canine, this Mastiff mix takes its home guardian role seriously. This hybrid will courageously protect its loved ones from any ill-intentioned individuals. 

My experience in dog handling has made me encounter the Daniff multiple times, and this is one of the largest hybrids I’ve had the opportunity to handle. They sometimes appear as thicker Great Danes or taller Mastiffs.

Regardless, the Great Dane Mastiff mix bears the dignified and elegant appeal of its parents. I can vouch that its massive size alone clearly gets the job done of intimidating intruders.

Further, this gentle giant can have many beautiful coat variations — from brindle and apricot like the Mastiff to blue, black, and harlequin, like what can be observed in Great Danes.

4. Doubull-Mastiff

Doubull Mastiff Bullmastiff Mastiff mix
Image credit: mmagerk / Instagram

Parent Breeds: Bullmastiff & Mastiff

The Doubull-Mastiff is a hybrid of two mastiff breeds such as the Bullmastiff and the Mastiff. The combination of these two dog breeds produces an ultimately fearless, powerful, and loving family companion.

As a descendant of two mastiff breeds, the Doubull-Mastiff is an extra-large canine that is alert and protective. 

With its mere size and appearance, meeting one in person can be an intimidating experience for many. But for those who are considered part of its pack, the Doubull-Mastiff is a sweet fellow who is anything but scary.

That said, training this mix is very crucial due to its size and strength. Proper manners and good behavior must be instilled during the puppy years. 

It can take a fair amount of patience, consistency, and assertiveness to successfully train a Doubull-Mastiff due to its independent streak.

With that, potential owners must carefully assess their capabilities before getting one.

5. Englian Mastiff

Englian Mastiff Neapolitan Mastiff Mastiff mix
Image credit: percy_the_mastiff / Instagram

Parent Breeds: Neapolitan Mastiff & Mastiff

If you are looking for a large dog that can serve as an exceptional guardian of your home, you have to meet the Englian Mastiff. This large mixed breed is a cross between the Mastiff and the Neapolitan Mastiff.

An Englian Mastiff has a calm demeanor and is immensely loyal to its humans, like its parent breeds. It is a dedicated and powerful defender, which makes it naturally suspicious of unfamiliar people.

Its dignified appearance is reflective of its formidable strength, standing between 24 and 31 inches in height and weighing around 110 to 230 pounds

It can also have wrinkly skin all over its massive body, which is a distinct trait of the Neapolitan Mastiff.

Meanwhile, due to the loose skin around its large lips, Englian Mastiffs tend to drool a lot. As such, tying a bandana around its neck can help keep your floors free from saliva.

6. Irish Mastiff

Irish Mastiff Irish Wolfhound Mastiff mix
Image credit: bailey_the_wolfhound / Instagram

Parent Breeds: Irish Wolfhound & Mastiff

As a cross between the Irish Wolfhound and the Mastiff, the Irish Mastiff is a reaffirmation of its parents’ greatest traits. 

This hybrid, also known as Irish Mastiff Wolfhound, is a dignified, calm, and courageous family companion.

It is an extra large dog that has a regal appeal with its tall stature and gentle aura. It can have a short straight coat like the Mastiff or be like its Irish Wolfhound parent and have a wiry, harsh coat. 

In addition, an Irish Mastiff is known to be tolerant and patient with children. It is likewise very alert and can serve as an excellent watchdog of the home.

But, as with many giant breeds, this mix’s lifespan tends to be short. Owners of Irish Mastiffs must make the most out of the limited time they have with this canine, as it can only live for around 6 to 10 years.

7. Mastador

Mastador Labrador Mastiff mix
Image credit: chroniclesofboomer / Instagram

Parent Breeds: Labrador Retriever & Mastiff

The Mastador is a mix of the powerful Mastiff and the highly energetic and friendly Labrador Retriever. This delightful hybrid is an extremely loving, gentle, and intelligent family companion.

Having a Labrador parent enables this Mastiff mix to be outgoing and accepting of other people and animals outside its family. It likewise inherits its eagerness and playful spirit from the Lab.

Meanwhile, its Mastiff parent passes on its skills as an exceptional guardian of the family to the Mastador. 

This mix also tends to be less active than the Labrador, as it inherits the calm and docile nature of the Mastiff.

When it comes to grooming and maintenance, potential owners must be prepared to allot time to regularly brush the Mastador as this mix tends to shed a moderate to a heavy amount of fur.

Fur shedding likewise increases exposure to dander, making the Mastador unsuitable for allergy sufferers.

8. Mastiff Shepherd

Mastiff Shepherd German Shepherd Dog Mastiff mix
Image credit: horton_mastiffshepherd / Instagram

Parent Breeds: German Shepherd Dog & Mastiff

The fierce-looking Mastiff Shepherd is a prized family dog due to its loyalty, intelligence, and affectionate personality. It is a superb protector, thanks to its German Shepherd and Mastiff lineage.

Also known as the German Shepherd Mastiff mix, this crossbreed’s appearance can vary depending on whether it takes more after its German Shepherd or Mastiff parent. 

In addition, the Mastiff Shepherd can have apricot, brindle, and fawn coat colors but can also sport several other colors like what can be seen in German Shepherds. 

As a dog behaviorist myself, I have had a lot of opportunities to work on training Mastiff Shepherds. Ideally, I would suggest that these dogs undergo proper socialization and obedience training at an early age.

This is because handling a strong dog of immense size can be difficult, especially if it has not learned proper manners and good behavior. Many of the Mastiff Shepherds that I have trained quite late take months to get out of their stubborn phase.

Meanwhile, watch a Mastiff Shepherd transform into a well-behaved canine in the video below:

1 Year Old GSD/Mastiff Mix | Best GSD/Mastiff Dog Training | Off Leash K9 | Board & Train | Oklahoma

9. Mastipoo

Mastipoo Poodle Mastiff
Image credit: mastiff_duckie / Instagram

Parent Breeds: Poodle & Mastiff

The Mastipoo is a remarkable combination of the Mastiff and the Poodle. This smart, lively, and alert mix also goes by the name Mastidoodle. 

A Mastipoo is super sweet and cuddly. It never seems to pass up on any opportunity to snuggle with its humans, something many pet lovers are sure to appreciate with this hybrid.

It is also an alert watchdog of the family. Depending on which parent it takes more after, it can be very friendly with strangers like Poodles or may tend to be distant with unfamiliar people like Mastiffs.

Like most mixed breeds, the exact physical appearance of the Mastipoo can vary. It can have the short, coarse coat of the Mastiff or the curly hair of the Poodle.

Its exercise requirements will also depend on whether it tends to be very active like the Poodle or more laid-back like the Mastiff.

10. Mountain Mastiff

Mountain Mastiff Bernese Mountain Dog Mastiff mix
Image credit: thelifeofthedoggos / Instagram

Parent Breeds: Bernese Mountain Dog & Mastiff

A gentle giant like the Mountain Mastiff is a dream family pet as it is very strong yet so sweet and calm. Its huge size matches the amount of happiness and love this crossbreed can give.

The Mastiff Bernese Mountain Dog mix is gentle with young kids and tends to do well with other pets. It is also easily trainable, especially when consistent and gentle training methods are used.

In addition, a Mountain Mastiff is also relatively easy to groom, only requiring regular brushing and occasional baths to stay clean and tidy. It can be prone to drool, though, so its mouth needs to be wiped often.

Like many large breed dogs, the Mastiff Bernese Mountain Dog can be prone to bloat. With this, it is best to avoid vigorous activities immediately before and after eating to help keep the Mountain Mastiff healthy. 

11. Mastweiler

Mastweiler Rottweiler Mastiff mix
Image credit: ericandfrancis / Instagram

Parent Breeds: Rottweiler & Mastiff

When you combine the burly and good-natured Mastiff with the confident and faithful Rottweiler, the result is an exceptional Mastweiler that is truly powerful, devoted, and calm.

It is a large companion and family guardian dog that lives to safeguard its humans. A Mastweiler is a strong and well-muscled hybrid that is very alert and clever.

And like the English Mastiffs and Rottweilers, this mix is expressive of its emotions and is devoted and loving towards its family.

Meanwhile, it is crucial for Mastweilers to be socialized and trained at an early age due to their territorial nature. Doing so enables them to live harmoniously with other animals.

Apart from physical activities, a Mastweiler also needs lots of mental stimulation to keep it from becoming bored. 

Fun exercises that hone problem-solving skills, like puzzles and obstacle courses, are recommended for Mastweilers.

12. Pit Mastiff

Pit Mastiff Pitbull Mastiff mix
Image credit: annabellsurbanadventures / Instagram

Parent Breeds: American Pitbull Terrier & Mastiff

One of the popular Mastiff mixes is the Pit Mastiff. With its incredible loyalty and profound love for its humans, it’s easy to see why this is a favorite choice for a family companion.

For starters, a Pit Mastiff is a product of pairing a Mastiff with a breed from the Pitbull family of breeds. 

This includes the American Pit Bull Terrier, American Staffordshire Terrier, Staffordshire Bull Terrier, and American Bully. 

Its physical traits and size can vary, but this crossbreed is ultimately a confident and dignified guardian of its family. 

While a Pitbull Mastiff mix can appear to look serious and menacing, this mix has a silly side to its personality, enjoying playtime and bonding with loved ones.

Meanwhile, for a Pitbull Mastiff mix to get along well with other pets, it must be socialized at a young age.

13. Saint Bermastiff

Saint Bermastiff Saint Bernard Mastiff mix
Image credit: mymotleybunch / Instagram

Parent Breeds: Saint Bernard & Mastiff

The Saint Bermastiff is one of the gentle giant crossbreeds. This charming Mastiff and Saint Bernard mix is a gentle yet fearless family companion.

As one of the gentle giants of the canine kingdom, the Saint Bermastiff is a family’s big companion with its sweet temperament and patience for little children.

Furthermore, Saint Bermastiffs are also great watchdogs as they are alert and brave. They do well with other dogs and animals, especially when accustomed to living with them at a young age. 

Some owners of massive breeds think that their dogs need rigorous exercise. However, as a dog handler for more than 10 years, I can validate that such huge breeds like the Saint Bermastiff will be content with daily walks with their humans to fill their daily energy needs.

Meanwhile, as a giant breed, the Saint Bermastiff’s short life expectancy is only around 6 to 10 years

Owners must ensure their good health by being wary of any signs of health problems such as bloat, heart disease, and cancer.

14. Akita Mastiff Mix

Akita Mastiff mix
Image credit: kelly.langfield / Instagram

Parent Breeds: Akita & Mastiff

The Akita Mastiff mix is a large dog with a friendly and dignified demeanor. This mixed breed is courageous and very loyal to its family, being an offspring of the Japanese or American Akita and the Mastiff.

On average, an Akita Mastiff can live for 6 to 13 years. It has an improved chance for a longer lifespan compared to the Mastiff, thanks to its Akita parent.

As both its parents are excellent protectors of their loved ones, the Akita Mastiff mix naturally follows suit with being a good guard dog.

With that, early training and socialization are very crucial for the Akita Mastiff mix due to its huge size and strong guarding instincts.

Meanwhile, grooming this hybrid is a pretty easy task as it does not require regular coat trimmings. A weekly brushing routine is enough to help maintain the beauty of its coat and keep it healthy.

15. Alaskan Malamute Mastiff Mix

Alaskan Malamute Mastiff mix
Image credit: just_a_lost_puppet / Instagram

Parent Breeds: Alaskan Malamute & Mastiff

The Alaskan Malamute Mastiff mix is a mixed breed that is affectionate, good-natured, and playful. It likewise has a strong work ethic, having parent breeds who are both from the working group

This mix is capable of performing diverse tasks, such as being a good guard dog, a skilled worker in search and rescue missions, and police and military work, like the Mastiff.

At the same time, it can also be a competent sled dog like the Alaskan Malamute, given the proper training and the opportunity to showcase its skills.

In my years of handling different dog breeds, I have observed most of the Alaskan Malamute Mastiff mixes I have handled have a high prey drive. While this mix can be great with kids, owners must have secured fenced yards to prevent this mix from suddenly chasing small animals.

This behavior is something that I have mostly observed in purebred Alaskan Malamutes, as well. Hence, to make it easier for owners to handle this large hybrid, I recommend subjecting them to early socialization and obedience training.

16. Anatolian Shepherd Mastiff Mix

Anatolian Shepherd Mastiff mix
Image credit: paperclipthedog / Instagram

Parent Breeds: Anatolian Shepherd & Mastiff

The smart, intensely loyal, and protective Anatolian Shepherd Mastiff mix is a mixed breed for assertive and firm owners. This mix has a very strong drive to protect its family pack.

It is dignified and calm but will wholeheartedly defend everyone it considers to be part of its pack. Owners are fortunate to have a pet as devoted and strong as this mix. 

With its supreme guarding instincts, it can naturally be wary and aloof with strangers. As such, the Anatolian Shepherd Mastiff mix needs to be socialized early on to get accustomed to being around other people.

If this mix is not properly socialized, it can get extremely shy or overprotective, and aggressive.

Meanwhile, due to its intelligence, the Anatolian Shepherd Mastiff mix is inclined to become self-reliant and unwilling to cooperate with training.

But with the right guidance, consistency, and patience, desired behavior can be successfully learned. 

17. Australian Cattle Dog Mastiff Mix

Australian Cattle Dog Mastiff mix
Image credit: kima_malone / Instagram

Parent Breeds: Australian Cattle Dog & Mastiff

An Australian Cattle Dog Mastiff mix is a beautiful mixed breed with great strength and enthusiasm. This crossbreed usually sports eye-catching brindle and mottled coat color patterns.

Coming from a line of energetic herders such as the Australian Cattle Dog or Blue Heeler, this mix can be quite active.

Canine sports such as agility, flyball, and rally are some activities this mix enjoys and does well in. Meanwhile, If it takes more after the English Mastiff, carting is more of this mix’s sporting activity.

Being a descendant of esteemed guardian dogs, the Australian Cattle Dog Mastiff mix is innately protective of its human pack and can be reserved with strangers.

But in the company of its loved ones, the Australian Cattle Dog Mastiff mix is affectionate and devoted. It gets along well with young children and other pets especially if introduced at a young age.

18. Australian Shepherd Mastiff Mix

Australian Shepherd Mastiff mix
Image credit: turtlemountainfarm / Instagram

Parent Breeds: Australian Shepherd & Mastiff

Australian Shepherd Mastiff mixes are great family dogs that are intelligent and active. They get along well with children and are very affectionate with their humans.

Due to their Aussie lineage, they can have gorgeous merle coat patterns, blue eyes, and furry medium-length coats. With this, they shed heavily and are not a good match for allergy sufferers.

This mixed breed can inherit the high energy of its Australian Shepherd parent and require lots of exercise in order to be physically and mentally fit.

But, it can also be moderately active like the Mastiff and be content with lounging beside its loved ones for the rest of the day after having been out for a few minutes of walking.

Meanwhile, owners are fortunate to be able to spend long years with their beloved Australian Shepherd Mastiff mix, as it has a lifespan of 6 to 15 years.

19. Beagle Mastiff Mix

Beagle Mastiff mix
Image credit: pamherzog_ / Instagram

Parent Breeds: Beagle & Mastiff

A unique mixed breed like the Beagle Mastiff mix is a joy to be around because of its happy energy, curious nature, and devotion to its family.

As there is a significant size difference between its parent breeds, every Beagle Mastiff mix can vary in size depending on which parent breed it takes after. These Mastiff mixes can be small to extra-large-sized dogs.

Like its Beagle parent, the Beagle Mastiff mix can come in several coat colors, including lemon and tricolor. Another signature trait of the Beagle Mastiff mix is its charming floppy ears. 

Meanwhile, this crossbreed has a strong desire to always be beside its humans and can be prone to separation anxiety if kept away from them for too long.

As such, owners must ensure to devote ample time to their Beagle Mastiff mix to prevent it from resorting to destructive behaviors due to anxiety.

20. Belgian Malinois Mastiff Mix

Belgian Malinois Mastiff mix
Image credit: mariaujelly / Instagram

Parent Breeds: Belgian Malinois & Mastiff

Belgian Malinois Mastiff mixes are excellent guardians of the family that are also very devoted, smart, and hardworking.

This mixed breed is agile and thrives on performing activities alongside family members. It goes without saying that ample exercise and quality time with its human pack is essential to its well-being.

That said, its affection for loved ones and enthusiasm for activity and play do not always extend to strangers, as the Belgian Malinois Mastiff mix can be aloof with unfamiliar people. 

Meanwhile, because of their genetic makeup, these hybrids tend to be larger dogs with an average minimum height of 22 inches

With this, it is crucial that their legs and joints be properly cared for, as they can be susceptible to illnesses common to large breeds such as elbow and hip dysplasia.

21. Border Collie Mastiff Mix

Border Collie Mastiff mix
Image credit: allaboutdogsphotography / Instagram

Parent Breeds: Border Collie & Mastiff

Crossing a Mastiff with a fluffy breed often results in a hybrid with an adorable appearance like the Border Collie Mastiff mix. It is a fluffy dog that is very intelligent, active, and devoted to its family.

It is also alert and wary of strangers. As such, this hybrid will need time to warm up to strangers. 

This mix, like the Border Collie, can have various beautiful coat colors and patterns, including merle and brindle. Meanwhile, its Mastiff parent allows this mix to reach a full-grown adult size of beyond 27 inches.

As an offspring of working dog breeds, the Border Collie Mastiff mix is inclined to be very energetic and keen on having a job to do to be contented and happily preoccupied.

With that, the Border Collie Mastiff mix’s idea of a perfect day ends with a cuddle time with its favorite human.

22. Borzoi Mastiff Mix

Borzoi Mastiff mix
Image credit: runamok_p.falco / Instagram

Parent Breeds: Borzoi & Mastiff

The Borzoi Mastiff mix is a dignified and regal-looking pet. Beyond its beautiful appearance, it is a prized companion dog with its calm demeanor and kind temperament.

Its features blend the physical characteristics of its Borzoi and Mastiff parents. It can have an elegant long nose like the Borzoi and charming large droopy ears similar to the Mastiff.

Furthermore, Borzoi Mastiff mixes can sport long or short coats in various color variations.

As a mixed breed with a hunting background, the Borzoi Mastiff mix can have a high prey drive. Due to this, a secured, high-fenced yard is necessary to keep it safe. 

In addition, training the Borzoi Mastiff mix can be a bit of a challenge as it is known to be strong-willed and independent. That said, a suitable owner of this mix should be one who is gentle, patient, and consistent.

23. Cane Corso Mastiff Mix

Cane Corso Mastiff mix
Image credit: konayqr / Instagram

Parent Breeds: Cane Corso & Mastiff

Pairing two dog breeds that are exceptional guardians produces a mixed breed with superior skills as a protector such as the Cane Corso Mastiff mix.

This crossbreed is among the best guard dogs and one of the toughest and most courageous canines. It is confident, intelligent, and possesses strong loyalty toward loved ones.

Its physical features can resemble either parent breed and can likewise have the same coat colors and markings as the Mastiff and Cane Corso.

Being an offspring of the Cane Corso and the Mastiff breed, this mix requires early socialization to become a well-adjusted adult.

Meanwhile, Cane Corso Mastiff mixes tend to be very active dogs that need to have sufficient physical and mental exercise. This is to prevent them from becoming bored and resorting to destructive behavior.

With this, it would need 1 to 2 hours of daily exercise to stay fit. 

24. Catahoula Leopard Dog Mastiff Mix

Catahoula Leopard Dog Mastiff mix
Image credit: bella_kona / Instagram

Parent Breeds: Catahoula Leopard Dog & Mastiff

The Catahoula Leopard Dog Mastiff mix is an agile and powerful guardian and watchdog. This family companion is playful, gentle, and devoted. 

Its short coat can come in a variety of colors, including red, blue, yellow, and apricot. These crossbreeds can likewise come in attractive brindle and leopard-like patterns. 

As an energetic canine, it is best suited for individuals and families who lead active lifestyles. These mixes are great walking and hiking partners.

While this versatile mixed breed is a serious worker, it is also a fun-loving family member. 

It does have a tendency to be self-willed, so dog owners must handle this canine with firm, calm, and assertive leadership.

In addition, this mix can be very protective and territorial, so it must be socialized at a young age to become more comfortable around other people and animals. 

25. Chesapeake Bay Retriever Mastiff Mix

Chesapeake Bay Retriever Mastiff mix
Image credit: kindleandbirch / Instagram

Parent Breeds: Chesapeake Bay Retriever & Mastiff

Mixing a purebred Mastiff and a Chesapeake Bay Retriever produces an affectionate, smart, and lively Chesapeake Bay Retriever Mastiff mix.

This large hybrid has a life expectancy of 6 to 13 years and takes more time to mature as compared to smaller dog breeds.

It thrives on performing activities with its owners and has the potential to be a great hunting partner, thanks to its Chesapeake Bay Retriever parent’s skills.

It is also an excellent guard dog that carefully watches over loved ones, an admirable trait inherited from both parent breeds. 

A mixed breed like the Chesapeake Bay Retriever Mastiff mix is an ideal match for experienced and active owners, as this mix’s strength, size, and strong-willed tendencies can make it very challenging for first-timers.

Meanwhile, grooming this mix is a fairly easy task. Brushing sessions every three days are sufficient to keep it tidy and manage its shedding.

26. Chihuahua Mastiff Mix

Chihuahua Mastiff mix
Image credit: picodegallo_thechi / Instagram

Parent Breeds: Chihuahua & Mastiff

The pairing of one of the largest dog breeds and the smallest dog breed can seem like an odd idea for many but owners of a Chihuahua Mastiff mix would surely beg to differ.

This crossbreed is charming, affectionate, and a truly loyal family companion that matches well with singles and families with older children.

Furthermore, it can be a tiny-sized pooch to a very big dog having a significantly wide height range of 5 to over 30 inches.

Due to the likelihood of producing large puppies, the pairing of the two breeds typically requires female Mastiffs to be the dams while male Chihuahuas are the sires to avoid birthing problems.

Meanwhile, early socialization is necessary for this mix as it can be territorial and suspicious of strangers. Training is likewise crucial to help establish boundaries and teach good behavior.

27. Chow Chow Mastiff Mix

Chow Chow Mastiff mix
Image credit: hershey_the_mastiff_chow / Instagram

Parent Breeds: Chow Chow & Mastiff

Chow Chow Mastiff mixes are dignified, powerful, and calm family dogs with innate good manners. This mixed breed is a great match for moderately active families and does not require long hours of exercise.

They are like giant teddy bears with their plush coats and sweet, expressive faces. In addition, the Chow Chow Mastiff mix can also have a unique blue tongue, a characteristic attribute of its Chow Chow parent.

These classy pets are descendants of magnificent guardians and hunters. As such, they possess strong protective instincts and good hunting skills like the purebred Mastiffs and Chow Chows.

When in the midst of family members, these dogs are very affectionate. But, in the presence of strangers, they are aloof and reserved.

Due to this, Chow Chow Mastiff mixes need early socialization to help them learn how to deal with strangers and other animals properly.

28. Coonhound Mastiff Mix

Coonhound Mastiff mix
Image credit: eringriff23 / Instagram

Parent Breeds: Coonhound & Mastiff

As a Mastiff mix that comes from a lineage of working dogs, the energetic Coonhound Mastiff mix thrives on performing activities with its human pack.

This hybrid is produced by pairing a purebred Mastiff with any of the coonhound breeds which includes the Black and Tan Coonhound, American English Coonhound, and Bluetick Coonhound.

As such, this active canine naturally possesses a superior sense of smell and excellent guarding instincts.

In addition, a Mastiff mixed with a coonhound is devoted, smart, and a brave family companion that would firmly protect its family from any threat or danger.

Meanwhile, Coonhound Mastiff mixes can be prone to chase small animals due to their strong prey drive. 

With this, owners must ensure their safety by maintaining a high-fenced yard and keeping them on leashes when outdoors to prevent them from instinctively running away to pursue their prey.

29. Corgi Mastiff Mix

Corgi Mastiff mix
Image credit: sirgibson / Instagram

Parent Breeds: Corgi & Mastiff

The Corgi Mastiff mix is one of the most affectionate and alert Mastiff mixes. Lucky owners of this mix get to enjoy having a vigilant watchdog and a perfect snuggle buddy at the same time.

This hybrid attempts to balance the tendency of the Mastiff to be aloof with strangers with its Corgi parent’s friendly and outgoing personality.

Corgi Mastiff mixes usually come in fawn color variations and can have short or medium-length hair. 

They do shed a lot, too. Thus, frequent brushing sessions are necessary to help avoid loose fur from spreading around the house.

Meanwhile, having parent breeds with significant size differences, predicting the adult size of the Corgi Mastiff mix can be pretty difficult. Its full-grown size can range from a small to an extra-large-sized pooch. 

This is something to consider for potential owners who have limited living space.

30. Doberman Pinscher Mastiff Mix

Doberman Pinscher Mastiff mix
Image credit: lewallen_dobies / Instagram

Parent Breeds: Doberman Pinscher & Mastiff

The magnificent Doberman Pinscher Mastiff mix is as powerful as it is stunning. This mix comes from a generation of great guard dogs and is absolutely courageous and loyal, like its parent breeds.

Doberman Pinscher Mastiff mixes are usually fawn-colored but can also have other coat colors similar to Dobermans. 

While its imposing size and appearance can easily scare off any intruder, the Doberman Pinscher Mastiff mix is utterly loving and affectionate toward its humans.

It is likewise known to be excellent with children due to its patience and caring personality.

In addition, with their intelligence and high energy, Doberman Pinscher Mastiff mixes are capable of excelling in several canine sports.

Competitive sports hosted by various kennel clubs like the American Kennel Club, such as agility, obedience, and tracking, are ideal activities for this mix.

31. Dogue de Bordeaux Mastiff Mix

Dogue de Bordeaux Mastiff mix
Image credit: klapanel1 / Instagram

Parent Breeds: Dogue de Bordeaux & Mastiff

A mastiff breed like the Old English Mastiff that is paired with another one such as the Dogue de Bordeaux may result in a wrinkly, lovable, and fearless companion such as the Dogue de Bordeaux Mastiff mix. 

This extra-large guardian canine with a massive head is revered for its intense loyalty and sweet temperament. And given its strong devotion to its family, it can also be very protective and quite territorial.

As such, early socialization is a must for this mix to prevent it from becoming aggressive or overly possessive. 

Meanwhile, like many large breeds, the lifespan of this Mastiff mix also tends to be pretty short. On average, this hybrid lives for only 5 to 10 years.

With this, owners must be keen on recognizing any symptoms of bloat and heart diseases like aortic stenosis. These life-threatening conditions are illnesses that commonly affect this mix.

32. French Bulldog Mastiff Mix

French Bulldog Mastiff mix
Image credit: lil_brotherbear_zym / Instagram

Parent Breeds: French Bulldog & Mastiff

The French Bulldog Mastiff mix is an easygoing and lively Mastiff mix. This charming pooch is an endearing family companion that loves to be constantly in the company of its humans. 

Though it is not recognized by the American Kennel Club due to being a mixed breed, it is still an outstanding canine that bears praiseworthy traits that are passed on by its parent breeds. 

French Bulldog Mastiff mixes are great playmates for kids as they are always up for a good time and are tolerant and gentle with them. 

While they rarely tend to bark, they are alert watchdogs that are fearless in protecting their humans. 

Meanwhile, the French Bulldog Mastiff mix’s short coat is very easy to maintain. Simple brushing sessions every week will suffice as a grooming routine. 

Furthermore, their adorable wrinkles must be carefully kept dry and clean to avoid skin irritations and possible infections.

33. Golden Retriever Mastiff Mix

Golden Retriever Mastiff mix
Image credit: quinnandcolt / Instagram

Parent Breeds: Golden Retriever & Mastiff

As one of the sweetest Mastiff mixes in this list, the Mastiff Golden Retriever mix bears the happy personality, extremely loving temperament, and intelligence of its parent breeds.

Being an offspring of the Golden Retriever, this mix can be very friendly and outgoing, even with strangers. Its comical personality is always a cause for laughter and amusement inside and outside the home.

In addition, having an alert and protective parent like the Mastiff allows the Golden Retriever Mastiff mix to have a courageous spirit and impeccable guarding instincts.

It is likewise easy to train due to its intelligence. That said, this mix must have enough daily mental stimulation and physical exercise as it can be prone to exhibiting destructive behaviors when bored.

Meanwhile, this hybrid tends to be a heavy shedder and needs to be frequently brushed to help avoid loose fur from sticking onto clothes and furniture.

34. Great Pyrenees Mastiff Mix

Great Pyrenees Mastiff mix
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Parent Breeds: Great Pyrenees & Mastiff

Pairing the Mastiff with the Great Pyrenees produces an elegant Great Pyrenees Mastiff mix that is patient, alert, and strong.

Great Pyrenees Mastiff mixes are usually light-colored and frequently sport varying shades of light brown to white coat colors. They can also have red, tan, and gray markings and black masks.

This gentle giant is an extremely affectionate family companion that forges strong bonds with its humans. But while it is gentle and kind, it is well-capable of fearlessly protecting its family. 

It’s worth noting that training this mix requires ample patience and consistency. This canine is inclined to be stubborn and independent, and learning commands can take a while.

Meanwhile, due to having a Great Pyrenees parent, this hybrid enjoys a longer life expectancy compared to the Mastiff. On average, the Great Pyrenees Mastiff mix can live for 6 to 12 years.

35. Greyhound Mastiff Mix

Greyhound Mastiff mix
Image credit: gillbuckley88 / Instagram

Parent Breeds: Greyhound & Mastiff

The Greyhound Mastiff mix is a unique combination of two purebreds that have existed for more than 2,000 years.

It is a large muscular dog with a deep chest that can either be slim like the Greyhound or stocky like the Mastiff.

It can likewise inherit the Greyhound’s grace and swiftness in movement or the outstanding strength of the Mastiff.

While it is not recognized by the American Kennel Club and no specific breed standard for this mix exists, the Greyhound Mastiff mix is still a remarkable family pet.

Greyhound Mastiff mixes are gentle and good-natured companions that are intelligent. They possess an independent nature but respond well to positive reinforcement training.

That said, they require patient and assertive owners who will raise them into good-mannered and well-behaved family dogs.

36. Leonberger Mastiff Mix

Leonberger Mastiff mix
Image credit: rebby1617 / Instagram

Parent Breeds: Leonberger & Mastiff

An elegant, playful, and super adorable Leonberger Mastiff mix is the result when the dignified Mastiff is paired with the graceful Leonberger. 

This large dog is a fantastic family pet that possesses a wonderful temperament. It adores its family and is especially patient with young ones. 

In addition, Leonberger Mastiff mixes also tend to be friendly with strangers. It likewise gets along with other pets, provided they are properly socialized at an early age. 

And while this mix is good-natured and sweet, it is able to guard and protect loved ones with great competence. Furthermore, training this mix is relatively easy due to its intelligence.

Meanwhile, taking care of the Leonberger Mastiff mix requires a steadfast commitment to frequent brushing as this dog tends to shed a lot. 

Daily brushing also helps keep its coat beautiful and tangle-free, especially if it inherits the lush coat of the Leonberger. 

37. Newfoundland Mastiff Mix

Newfoundland Mastiff mix
Image credit: piper_newfie_mastiff / Instagram

Parent Breeds: Newfoundland & Mastiff

The Newfoundland Mastiff mix is a dignified, devoted, and ultra-sweet large dog that fits well with families that take delight in taking care of gentle giants.

Like its Mastiff and Newfoundland parent breeds, this mix possesses great patience and a kind temperament, making it a good match for households with both young and old family members.

They are likewise known to be great around other pets due to their gentle nature. Newfoundland Mastiff mixes are also quiet house dogs that rarely bark. But these furry family members are very vigilant, too.

As such, you’ll only often hear them bark when they are trying to warn their owners of possible threats or unusual sounds around their property.

Although they are not hyperactive dogs, these hybrids still need enough daily exercise to stay fit. Walking and carting are good exercise activities for the Newfoundland Mastiff mix.

38. Presa Canario Mastiff Mix

Presa Canario Mastiff mix
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Parent Breeds: Presa Canario & Mastiff

The Presa Canario Mastiff mix is another excellent guardian Mastiff hybrid. This canine with a muscular body is an adept protector of the home and its family with its strength, courage, and vigilance. 

Presa Canario Mastiff mixes are large dogs with massive heads. Another characteristic trait of these canines is their black masks. They also have short coats that come in shades of brown, fawn, silver, and gold.

And having parent breeds that served as protectors of cattle from wild dogs, the Presa Canario Mastiff mix is naturally alert and powerful enough to subdue any home intruder.

That said, this crossbreed has a tendency to be very aloof with strangers and can be aggressive with other dogs. 

Hence, a Presa Canario Mastiff mix is best suited to experienced and dedicated owners who can provide constant training and socialization to help this cross become a well-adjusted family pack member.

39. Pug Mastiff Mix

Pug Mastiff mix
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Parent Breeds: Pug & Mastiff

If you are in search of a laid-back and sweet family companion, then you must meet the Pug Mastiff mix. 

Among the various mixed breeds, this Mastiff mix is uniquely charming with its adorable appearance and amiable personality. 

This hybrid with a signature black mask can be a toy-sized pooch like its Pug parent breed or be more like the giant Mastiff.

In addition, Pug Mastiff mixes are even-tempered dogs that do well with children. They are also cheerful and very affectionate towards loved ones.

When it comes to their activity level, these crossbreeds have a reputation for being lazy dogs, as they don’t crave too much physical activity.

Meanwhile, the Pug Mastiff mix can be a moderate to heavy shedder. As such, it needs to be brushed often to help remove dead hair and help distribute natural skin oils.

40. Rhodesian Ridgeback Mastiff Mix

Rhodesian Ridgeback Mastiff mix
Image credit: _bridyck / Instagram

Parent Breeds: Rhodesian Ridgeback & Mastiff

The dignified and clever Rhodesian Ridgeback Mastiff mix is a loving and protective companion dog. This large-sized cross is a moderately-active canine deeply devoted to its humans.

Mixed breeds like the Rhodesian Ridgeback Mastiff mix remarkably combine the features of their parent breeds. 

This cross can have the lean and muscular body of Rhodesian Ridgebacks and possess the massive heads of Mastiffs.

It is patient and gentle with kids but is usually reserved with strangers. It likewise has an independent streak, and its stubborn nature can make training challenging, especially for first-time owners.

Furthermore, a Rhodesian Ridgeback Mastiff mix can possess a high prey drive which makes having a high-fenced yard essential to keeping it safe.

Due to its intelligence, this mix requires sufficient mental stimulation to prevent it from becoming destructive due to boredom. Mind exercises like puzzle games help to keep this Mastiff mix happily preoccupied.

41. Shar-Pei Mastiff Mix

Shar Pei Mastiff mix
Image credit: spookysharpei / Instagram

Parent Breeds: Chinese Shar-Pei & Mastiff

With its confidence, strength, and protective nature, the Shar-Pei Mastiff mix is truly a one-of-a-kind family companion. It is dignified and extremely loyal to its humans.

This mix can be a medium to extra-large-sized pooch with gorgeous wrinkles and a black mask like its Shar-Pei and Mastiff parents. 

As an offspring of the Chinese Shar-Pei and the Mastiff, this dog inherits the remarkable guarding instincts of its parent breeds. It is a reliable defender of the home, which makes this mix naturally wary of strangers.

While it is a faithful companion, the Shar-Pei Mastiff mix tends to be self-willed and requires patience with training. Given this, it is best to stick with reward-based training methods when handling this mix. 

In addition, this crossbreed’s territorial nature can make it difficult to get along with other dogs without proper socialization. As such, exposure to other animals during puppyhood is important.

42. Shih Tzu Mastiff Mix

Shih Tzu Mastiff mix
Image credit: bullshih.pedro / Instagram

Parent Breeds: Shih Tzu & Mastiff

The good-natured, mischievous, and lively Shih Tzu Mastiff mix is a delightful family pet with unique physical traits and personality.

This affectionate mix is the result of the unlikely pairing of the extra-large Mastiff dog breed and the toy-sized Shih Tzu. As such, an adult Shih Tzu Mastiff mix can be anywhere between 9 and 30 inches in terms of height.

It can have a short coat like the Mastiff or have the long, flowy hair of a Shih Tzu. There are instances where this mix will have a combination of short and long hair in different areas of the body.

Shih Tzu Mastiff mixes are great for families with children due to this hybrid’s patience and gentleness. It also tends to do well around other pets. 

However, this mix can also be pretty stubborn and must be handled with patience and consistency to train successfully.

43. Siberian Husky Mastiff Mix

Siberian Husky Mastiff mix
Image credit: angiesita / Instagram

Parent Breeds: Siberian Husky & Mastiff

The Siberian Husky Mastiff mix, also known as Mastiff Husky mix, is an alert, gentle, and dignified companion dog.

It has a muscular physique and a deep chest. As it also carries the genes of the Mastiff, a Mastiff Husky mix tends to be a larger dog in comparison to its Husky parent. 

Having parent breeds renowned for their dedication to their families makes this mix one of the most loyal and loving dogs. 

And like many Mastiff mixed breeds, it is fond of children and loves being included in family activities.

But depending on which parent trait it inherits, it can be very friendly with strangers like the Husky or be reserved, similar to the Mastiff.

That said, this mix must be trained and socialized during puppyhood to help curb its territorial instincts and avoid aggressive behavior toward other dogs, a trait common among unsocialized Mastiffs.

Final Thoughts

Mastiff mixed breeds are truly great family dogs as they are able to carry both the wonderful traits of the Mastiff and their other parent breeds.

Their ability to blend, enhance and balance these traits make each and every Mastiff mix unique and better suited for specific individuals and families.

If you are planning on owning one, carefully consider the traits and specific needs of the Mastiff mix you want to take home to ensure that you are a good fit for each other.

Owning one will indeed be a very rewarding experience as the great love and loyalty these Mastiff mixes show toward their humans are undoubtedly as powerful and precious as these dogs are.

Which among the Mastiff mixes is a perfect match for you and your family? Let us know through the comments below!

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